ObjectiveTo evaluate the clinical significance of CT\|guided percutaneous lung biopsy in the diagnosis of slowly resolving pneumonia,chronic pneumonia and refractoriness pneumoniaMethodsA total of 71 patients admitted in Midi hospital from January 2014 to May 2015，who met the diagnostic criteria of slowly resolving pneumonia,chronic pneumonia and refractoriness pneumonia，were divided into two groups,29 cases in non\| lung biopsy group（Group A），42 cases in CT\|guided percutaneous needle lung biopsy group（Group B），Group B gave the corresponding treatment according to the results of lung biopsyResultsIn Group B,the inspection of etiology had high positive rate(4285%)，and the diagnosis rate was 7381%，the averaged length of stay was shortened obviously，the averaged hospitalization expenses was reduced distinctly，the application time of antibiotics was shortened，the adverse drug reactions was reduced，the differences between the two groups were statistically significance（P＜005）ConclusionCorresponding treatment was adopted based on the results of lung biopsy,it can shorten the period of treatment significantly,reduce the adverse drug reactions effectively,reduce the averaged hospitalization expenses,and achieve good economic and social benefitsKey Words:CT\|guided;Lung biopsy;Slowly resolving pneumonia;Chronic pneumonia;Refractoriness pneumonia