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电子期刊 >> 正文 |
| 大剂量N\|乙酰半胱氨酸对慢性阻塞性肺疾病治疗效果的影响 |
| 作者：沈明 周宏宇 倪丽丽 |
| 单位：中国医科大学第八临床学院鞍钢总医院 辽宁 鞍山 114002 |
| 关键词：大剂量N\|乙酰半胱氨酸 慢性阻塞性肺疾病 肺功能 |
| 分类号：R 563 |
| 出版年,卷(期):页码：2016,33(2):128-129 |
| 摘要： |
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目的探讨大剂量N\|乙酰半胱氨酸治疗慢性阻塞性肺疾病患者疗效。方法选择80例符合入选标准的COPD患者， 随机分为治疗组(42例)和对照组(38)例，治疗组在常规治疗基础上，加用N\|乙酰半胱氨酸600 mg，3 次/天，连用3 个月;对照组仅给予常规治疗3个月后观察两组呼吸功能的变化。结果2个月后，治疗组第1秒用力呼气容积用力肺活量氧分压(PaO2 )和二氧化碳分压(PCO2 )较治疗前有显著改善(P＜005)，对照组治疗前后无明显改善(P＞005)。结论在COPD的常规治疗基础上加用大剂量N\|乙酰半胱氨酸，能明显改善患者的肺功能及预后。 关键词：大剂量N\|乙酰半胱氨酸;慢性阻塞性肺疾病;肺功能
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ObjectiveTo investigate the high dose of N\|acetylcysteine（NAC） for chronic obstructive pulmonary disease.Methods80 patients met the inclusion criteria of the COPD were randomly divided into treatment group (42 cases) and control group (38 cases).In the treatment group,based on the routine treatment,N acetylcysteine was combined with 600 mg 3/d for consecutively 3 months;in the control group,only routine treatment was received for 3 months.The changes of respiratory function were observed between the two groups.ResultsAfter 2 months,1st second forced expiratory volume, forced vital capacity of oxygen partial pressure (PaO2) and partial pressure of carbon dioxide(PCO2) in the treatment group were improved significantly than before (P＜005),those were no significantly improved in the control group (P＞005).ConclusionBased on the conventional treatment,high dose of NAC being used for COPD,can significantly improve lung function and prognosis of the patients.Key Words:High dose N\|acetylcysteine;Chronic obstructive pulmonary disease;Pulmonary function |
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| 参考文献： |
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1］中华医学会呼吸分会慢性阻塞性肺疾病(COPD)诊治规范(草案)\[J\]中华结核和呼吸杂志,2013,20(4):199\|203 \[2\]陈灏珠实用内科学\[M\]13版北京:人民卫生出版社,2012：1743\|1744
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《中国冶金工业医学杂志》 |