中国冶金工业医学杂志

无症状高尿酸血症与陈旧性心肌梗死预后的关系*

分类号：R 5222

出版年,卷(期):页码：2016,33(3):249-251

摘要：

目的探讨无症状高尿酸血症与陈旧性心肌梗死患者预后的关系。方法顺序收集陈旧性心肌梗死患者81例，分为陈旧性心肌梗死组（OMI组）与陈旧性心肌梗死伴无症状高尿酸血症组（OMI伴无症状HUA组），平均随访(1609±506)个月。通过Kaplan\|Meier生存曲线及COX回归，分析无症状高尿酸血症与陈旧性心肌梗死患者预后的关系。结果（1）随访期间共发生心血管终点事件29例,发生率为358%。（2） OMI组与OMI伴无症状HUA组比较左室射血分数、GFR差异具有统计学意义。（3）经Kaplan\|Meier生存曲线分析示：OMI伴无症状HUA组心血管终点事件发生率明显高于OMI组。（4）COX回归分析显示：COX回归单因素分析显示，以心血管事件为终点时，风险比例(HR)为236(95%CI 112～501，P＜005)，多因素COX回归分析调整年龄、吸烟、高血压、糖尿病等后，风险比例(HR)为250(95%CI 018～089，P＜005)。结论无症状高尿酸血症与陈旧性心肌梗死患者预后密切相关，无症状高尿酸血症是预测OMI患者心血管终点事件的危险因素。

关键词：陈旧性心肌梗死；无症状高尿酸血症；预后

ObjectiveTo explore the relationship between asymptomatic hyperuricemia and the prognosis in the patients with old myocardial infarctionMethods81 cases of old myocardial infarction were divided into old myocardial infarction(OMI group)and old myocardial infarction with asymptomatic hyperuricemia group(OMI with asymptomatic HUA group),mean follow\|up time was 1609±506 months,the relationship of asymptomatic hyperuricemia and the prognosis in the patients with old myocardial infarction was analyzed by Kaplan\|Meier survival curves and COX regressionResults1The total cardiovascular endpoint events occurred in 29 cases during follow\|up,the rate was 358%2The differences of LVEF,GFR in OMI group and OMI with asymptomatic HUA group were statistically significant3Kaplan\|Meier survival curve analysis showed that the cardiovascular event incidence rates in OMI with asymptomatic HUA group were significantly higher than that in OMI group4COX regression analysis showed:COX regression univariate analysis showed that when at the end point of cardiovascular events,the proportion of hazard ratio(HR)was 236(95%CI112\|501,P＜005),multivariate COX regression analysis after adjusted for age,smoking,hypertension,diabetes,HR was 250(95% CI 018\|089,P＜005)ConclusionAsymptomatic hyperuricemia is closely related with the prognosis in patients with old myocardial infarction and is a risk factors forecasting cardiovascular endpoint events in patients with OMIKey Words:Old myocardial infarction；Asymptomatic hyperuricemia；Prognosis

基金项目：

内蒙古自治区医疗卫生科研计划项目（201302133）

作者简介：

参考文献：

1］郭丽，张丽，曲红玉，等老年心力衰竭患者血清尿酸水平变化的临床分析［J］心血管康复医学杂志，2007，16(2):131\|157

\[2\]桃春，许顶立，沈倩波，等慢性心力衰竭患者血尿酸水平与左室重构程度关系的探讨［J］临床心血管病杂志，2008，24(3):253\|255

\[3\]Kang D H,Nakagawa T,Feng L,et alA role for uric acid in the progression of renaL disease\[J\]J Am Soc Nephrol,2002,13(12):2888\|2897

\[4\]Sánchez\|Lozada LG,Tapia E,Santamaría J,et alMild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats\[J\]Kidney Int,2005,67(1):237\|247

服务与反馈：

【文章下载】【加入收藏】