中国冶金工业医学杂志

多西他赛和顺铂联合放射疗法同步治疗局部晚期鼻咽癌的临床对比

作者：李士猛

分类号：R 73

出版年,卷(期):页码：2016,33(5):499-500

摘要：

目的对比分析多西他赛和顺铂联合放射疗法同步治疗局部晚期鼻咽癌的临床疗效。方法将46例局部晚期鼻咽癌患者随机分为对照组与研究组，各23例，对照组采用顺铂联合放射疗法，研究组采用多西他赛联合放射疗法。观察对比两组患者治疗后1个月疗效与不良反应情况。结果研究组鼻咽部病灶治疗总有效率为8444%，对照组为8222%，差异无统计学意义（P=045）；研究组颈部淋巴结治疗总有效率为8544%，对照组为8667%，差异无统计学意义（P=035）；研究组胃肠道反应、口腔黏膜反应等发生率明显低于对照组，差异有统计学意义（P＜005）。结论多西他赛联合放射疗法治疗局部晚期鼻咽癌疗效和顺铂联合放射疗法接近，但该疗法不良反应少，值得推广应用。

关键词：放射疗法；顺铂；多西他赛；局部晚期鼻咽癌

Abstract:ObjectiveTo compare the clinical efficacy of docetaxel and DDP combined with synchronous radiotherapy for locally advanced nasopharynx cancer.MethodsFrom April 2013 to March 2015,46 cases of locally advanced nasopharynx cancer were randomly divided into control group and research group,23 cases in each group.The patients in research group received docetaxel combined with synchronous radiotherapy and DDP combined with synchronous radiotherapy was received in control group.The clinical efficacy and adverse events 1 month after treated in two groups were evaluated and compared.ResultsThe total treatment effective rate in the research group was 8444% and 8222% in the control group,the difference was no statistically significant (P=045).The treatment effective rate of cervical lymph node in the research group was 8544% and 8667% in the control group,the difference was no statistically significant（P=035）.The reaction rates of gastrointestinal and oral mucosa in the research group were inferior to the control group,the difference was statistically significant (P＜005).ConclusionThe efficacy of docetaxel combined with synchronous radiotherapy is similar with DDP combined with synchronous radiotherapy in locally advanced nasopharynx cancer,but it has much less adverse events and is worthy of promotion and application.Key Words:Radiotherapy;DDP;Docetaxel;Locally advanced nasopharynx cancer

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参考文献：

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