Abstract：ObjectiveTo observe and explore propofol in general anesthesia on postoperative cognitive function in elderly patients with surgery MethodsFrom August 2015 to December 2016 78 cases in anesthesia department of our hospital were randomly divided into observation group and control group，in the control group with inhaling isoflurane 10%~25%，intravenous fentanyl 10 μg/（kg·h）maintain anesthesia；the observation group with injection pump infusion of propofol 40~60 mg/（kg·h）and fentanyl 10 μg/kg The postoperative spontaneous breathing recovery time，eye open time，recovery time of directional force and 6 hours，12 hours，24 hours after anesthesia simple intelligence scale（MMSE）score changes in two group were observed ResultsAwakening quality after waking up in control group improved more significantly than that in observation group,with significant difference（P＜005） MMSE score after 6 hours，12 hours in the control group increased more dramatically than observation group ,with significant difference（P＜005），the MMSE score postoperative 24 hours in two groups was no significant difference（P＞005） ConclusionPropofol can significantly enhance quality after general anesthesia，fasten postoperative recovery of cognitive function，be suitable for elderly patients，and be worthy of being promotedKey Words:Propofol；General anesthesia；Elderly surgery；Cognitive function