中国冶金工业医学杂志

替格瑞洛对急性冠状动脉综合征患者炎性因子水平、PAR及心功能的影响

作者：刘瑞浩1 陈荣莹2

单位：1中国医科大学第八临床学院鞍钢集团总医院辽宁鞍山 114002 2中国劳动关系学院卫生所

分类号：R 54

出版年,卷(期):页码：2017,34(6):625-626

摘要：

摘要：目的研究替格瑞洛对急性冠状动脉综合征患者炎性因子水平、PAR及心功能的影响。方法按照纳入排除标准选择我院在2015-2016年期间收治的150例急性冠状动脉综合征患者，随机分为观察组和对照组，每组各75例。两组患者均在接受常规治疗基础上，对照组加氯吡格雷治疗，观察组加替格瑞洛治疗。对两组患者接受治疗前后的炎性因子、PAR及心功能情况进行比较。结果治疗前两组患者的hs\|CRP、TNF\|α、MMP\|9、IL\|6等指标，PAR，心功能指标，如E/A，LVEDD，LVEF等比较差异不显著；治疗后，两组各指标与治疗前相比，差异具有统计学意义（P＜005），且观察组各指标均优于对照组。结论对于急性冠状动脉综合征患者在常规治疗基础上使用替格瑞洛进行治疗，可以强化治疗效果，改善患者临床症状，值得推广应用。关键词：替格瑞洛；急性冠状动脉综合征；炎性因子；PAR；心功能

Abstract：ObjectiveTo study the effect of ticagrelor on the levels of inflammatory factors，PAR and cardiac function in patients with acute coronary syndromes Methods150 patients with acute coronary syndromes were enrolled in our hospital from 2015 to 2016 according to the inclusion criteria，and were randomly divided into two groups Two groups of patients were treated with conventional therapy，and then clopidogrel were used in the control group，ticagrelor were used in observation group The inflammatory factors，PAR and cardiac function were compared between the two groups before and after treatment ResultsThe levels of hs\|CRP，TNF\|α，MMP\|9，IL\|6，PAR and cardiac function in E/A，LVEDD and LVEF before treatment were not significantly different between the two groups，but after treatment there were statistically significant（P<005） ConclusionsFor patients with acute coronary syndrome the use of ticagrelor based on the conventional treatment ，can strengthen the treatment effect，improve the clinical symptoms，be worthy of promotion and applicationKey Words:Ticagrelor;Acute coronary syndrome;Inflammatory factors;PAR;Cardiac function

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参考文献：

[1\]逯豫霞，李劭凝，崔超血必净注射液联合替格瑞洛和阿司匹林治疗急性冠脉综合征的临床研究\[J\]现代药物与临床，2016，（7）：1007\|1011

\[2\]梁茜，杨希立，张健瑜，等替格瑞洛对糖尿病合并急性冠脉综合征患者冠状动脉介入治疗术后炎性因子水平的影响研究\[J\]中国全科医学，2016，（7）：799\|802，812

\[3\]朱永宏，贾国良，周妙，等替格瑞洛治疗41例急性冠状动脉综合征患者的临床疗效\[J\] 中国介入心脏病学杂志，2013，（6）：374\|376

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