Abstract：ObjectiveTo investigate the changes of plasma soluble fractalkine（sFKN），tumor necrosis factor\|α（TNF\|α）levels and its potential role of coronary artery lesions of patients with Kawasaki disease（KD） MethodsThirty\|eight inpatient children with KD in department of pediatrics of our hospital from June 2015 to Dec 2016 were collected and divided into two groups according to results of echocardiography：coronary artery lesion（CAL）group（n=16）and non\|coronary artery lesion（NCAL）group（n=22） Twenty healthy children in the same period were chosen as the control group The levels of plasma sFKN and TNF\|α were measured by enzyme\|linked immunosorbent assay（ELISA）respectively ResultsCompared with the control groups，plasma sFKN and TNF\|α levels were significantly elevated in the acute phase of KD In the subacute phase of KD，they were significantly lower The plasma sFKN ,TNF\|α levels of CAL group were higher than NCAL group in the acute phase of KD and they were still higher in the subacute phase of KD，but the difference was not statistically significant（P＞005） The correlation analysis show that the plasma sFKN levels was positively correlated with TNF\|α levels in the acute phase of KD ConclusionsThe plasma sFKN and TNF\|α are potential pathological factors in the formation of KD vasculitis and coronary artery lesionsKey Words:Kawasaki disease;Soluble fractalkine;Tumor necrosis factor\|α;Coronary artery lesions