中国冶金工业医学杂志

普萘洛尔联合595脉冲染料激光治疗婴幼儿皮肤真性血管瘤76例临床分析

作者：白艳玲1 邹凌云2 顾菲3

单位：1本溪市金山医院皮肤科辽宁本溪 117000 2北京新世纪儿童医院皮肤科 3首都儿研所附属儿童医院皮肤科

分类号：R 7322

出版年,卷(期):页码：2018,35(1):6-7

摘要：

摘要：目的探讨口服普萘洛尔治疗婴幼儿皮肤真性血管瘤停药后，再应用595脉冲染料激光治疗的临床疗效。方法对2013年7月至2015年6月期间首都儿研所附属儿童医院皮肤科门诊就诊的239例皮肤真性血管瘤患儿给予口服普萘洛尔治疗。剂量为第1天05 mg/kg，第2天1 mg/kg，第3天及以后2~3 mg/kg，疗程为5~13个月，平均7个月，停药的平均年龄为28个月。治疗结束停药后，局部仍有瘤体残留的76例患儿皮损部位再序列接受美中互利公司生产的Vbeam 595 nm脉冲染料激光治疗，治疗4~6次，间隔4~6周，随访6个月，观察其疗效及并发症。结果本组76例患儿疗效良好，序列接受激光治疗后，局部遗留的瘤体均有明显消退，局部外观明显改善，达到治愈标准；4例出现水疱、破溃、结痂，1周后愈合，无瘢痕遗留。1例由于搔抓出现局部感染，2周后愈合。2例出现色素脱失，1例出现色素沉着，随访6个月后均自行恢复。1例局部皮肤纹理改变，随访6个月后较前有所改善。结论对口服普萘洛尔停药后仍有瘤体残留的血管瘤患儿，应用染料激光治疗，血管瘤快速消退，遗留痕迹轻或无，不良反应少，疗效确定且安全，患儿家属满意度高。关键词：普萘洛尔；脉冲染料激光；婴幼儿血管瘤

Abstract：ObjectiveTo investigate the effect of 595 nm pulsed dye laser（PDL）on infantile hemangioma after propranolol treatment Methods239 cases of skin hemangioma were treated with oral propranolol treatment The dose was 05mg/kg on the first day，1 mg/kg on the second day，2~3 mg/kg on the third day and 3 days laterThe course of treatment was from 5 to 13 months，with an average of 7 months，the average age of withdrawal was about 28 months All the patients were from the department of dermatology of Children's Hospital Affiliated to Capital Institute of Pediatrics from July 2013 to June 2015By the end of treatment after propranolol，there were still 76 cases of local residual tumor were received 595 nm PDL of Chindex international，Incfor 4~6 times with interval of 4~6 weeksAfter 6 months of follow\|up，curative effect and complications were observed Results76 infantile cases obtained excellent effect，the residual hemangiomas were decreased after PDL treatment，local appearance were improved significantly，reaching the standard of cureTemporary side effects included blisters，ulceration，crusting in 4 cases（526％）had healed after 1 weeks，and had no scar Local infection due to scratching in 1 cases（132％）had healed after 2 weeks Hyper\|pigmentation in 1 cases（132％），hypo\|pigmentation in 2 cases（263％），they all disappeared after 6 months Local skin texture had some changed in 1 case（132%）and improved after follow\|up for 6 months ConclusionPDL is effective in the treatment of residual hemangiomas after propranolol treatment Its adverse reactions are less，the effect of therapy is safe and high\|performance，with satisfaction of family membersKey Words:Propranolol；Pulsed dye laser；Infantile hemangioma

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作者简介：

参考文献：

参考文献\[1\]金云波，林晓曦，叶肖肖，等普萘洛尔作为严重婴幼儿血管瘤一线治疗的前瞻性研究\[J\]中华整形外科杂志，2011，27（3）：170\|173

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