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围绝经期妇女骨质疏松症153例临床观察
作者:侯小赛 韩超前* 
单位:内蒙古医科大学第二附属医院 内蒙古 呼和浩特 010010 
关键词:围绝经期 骨质疏松 骨密度 雌激素 骨代谢指标 
分类号:R 1952
出版年,卷(期):页码:2018,35(3):252-254
摘要:

 目的 观察围绝经期妇女不同时期骨密度的变化情况,为临床防治围绝经期骨质疏松症提供理论指导。方法选取153例围绝经期妇女为研究对象,按照绝经时间分为3组,绝经前期51例(A组),平均年龄(4256±426)岁;绝经期48例(B组),绝经时间<1年,平均年龄(4812±459)岁;绝经后期54例(C组),绝经时间>1年,平均年龄(5223±433)岁,3组均采用双能X线骨密度仪测定受试者腰正位(L2~4)及左髋部(股骨颈)、大转子、华氏三角区部位的骨密度(BMD)情况;同时检测其血清雌二醇(E2)水平、骨代谢指标\[包括I型羧基末端肽(CTX)、氨基酸中段骨钙素(NMID)、I型前胶原氨基端前肽(PINP)\]的情况。结果(1)C组较A组和B组各部位BMD显著降低(P<005);B组较A组腰L2~4、股骨颈部位的BMD显著降低(P<005);B组较A组大转子、华氏三角区部位的BMD值降低不明显(P>005)。(2)各组雌激素水平、骨代谢指标的情况表明,C组较A组和B组血清E2值呈显著下降趋势,NMID、CTX、PINP水平呈显著升高趋势;B组较A组血清E2值明显下降,NMID、CTX、PINP水平明显升高,差异均有统计学意义(P<005)。结论围绝经期妇女随绝经年龄增加,骨质疏松症明显上升,因此预防工作应尽早开始。关键词:围绝经期;骨质疏松;骨密度;雌激素;骨代谢指标 

 Abstract:ObjectiveTo observe the change of bone density in peri\|menopausal women in different periods and provide theoretical guidance for clinical prevention and treatment of postmenopausal osteoporosis MethodsFifty\|one menopausal women were divided into three groups according to menopause,51 patients(Group A)with an average age of (4256±426);48 menopause(Group B),menopause time<1 year,the average age of (4812±459);postmenopausal 54 cases(Group C),menopause time> 1 year,the average age of (5223±433) The bone mineral density(BMD)of the lumbar anteroposterior(2~4)and the left hip(femoral neck),major rotator and Fahrenheit triangle were measured by dual energy X\|ray absorptiometry;While detecting the serum levels of estradiol(E2)and bone metabolic indices including type I carboxy terminal peptide(CTX)and amino acid in the middle before osteocalcin(NMID),type I collagen amino terminal propeptide(PINP) Results(1)Compared with group A and group B,BMD in group C decreased significantly(P<005);the BMD of L2~4 and femoral neck in group B was significantly lower than that in group A(P<005) The BMD of major rotator and Fahrenheit triangle in group B was not significantly lower than that in group A(P>005)(2)The estrogen levels,bone metabolism index in groups showed that serum E2 values were significantly lower and NMID,CTX,PINP levels was significantly increased in group C than that of group A and group B,(P<005);the serum E2 values were significantly lower and the levels of NMID,CTX and PINP were significantly higher in group B than that of group A,and the differences were statistically significant(P<005) ConclusionWith menopause age increased,osteoporosis increased significantly for peri\|menopausal women,so the prevention work should begin as soon as possibleKey Words:Peri\|menopausal period;Osteoporosis;Bone mineral density;Estrogen;Bone metabolism index

基金项目:
作者简介:
参考文献:

 [1\]WHO九十年代绝经研究\[M\]刘云嵘译葛秦生审校北京:人民卫生出版社,1998:11\|12

\[2\]Report of a WHO Study Group Assessment of fracture risk and its application to screening for postmenopausal osteoporosis\[J\] World Health Orqan Tech Rep Ser,1994,843:1\|129
\[3\]王国平,陈天江雌激素对去卵巢小鼠肿瘤坏死因α、白细胞介素6水平的影响\[J\]生殖医学杂志,2011,20(5):35\|37
\[4\]欧萌萌,黄建荣绝经后妇女骨质疏松症患者血清β\|Crosslaps、PINP和N\|MID 检测的评价\[J\]标记免疫分析与临床,2010,18(4):238\|240
\[5\]刘俏平,顾青,葛雯莉,等社区中老年人骨转换标志物的对比分析\[J\]放射免疫学杂志,2010,23(1):96\|97
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