中国冶金工业医学杂志

大剂量N-乙酰半胱氨酸对有创机械通气的职业相关性阻塞性肺病患者PCT、IL-6、CRP的影响

作者：沈明

分类号：R 563

出版年,卷(期):页码：2019,36(2):133-134

摘要：

摘要：目的探讨大剂量N-乙酰半胱氨酸对有创机械通气患者的影响。方法随机将在我院呼吸科重症室行有创机械通气治疗的职业相关性阻塞性肺病患者分为观察组及对照组。对照组给予常规治疗，观察组在对照组基础上给予N-乙酰半胱氨酸鼻饲，600 mg/次，2次/日。观察治疗前及治疗72 h后PCT、CRP、IL-6的水平；计算患者气管插管时间及ICU住院时间。结果治疗前两组PCT、CRP及IL-6水平比较差异均无统计学意义（P＞0.05）；治疗后两组PCT、CRP及IL-6水平均较治疗前降低，且观察组PCT、CRP及IL-6水平均低于对照组，P＜0.05；观察组气管插管时间和ICU住院时间短于对照组，总有效率高于对照组，差异均有统计学意义（均P＜0.05）。结论 N-乙酰半胱氨酸有助于提高COPD患者成功脱机率，缓解脱机后急性发作。
关键词：N-乙酰半胱氨酸；机械通气；职业相关性阻塞性肺病

Abstract：Objective To investigate the effect of high-dose N-acetylcysteine on patients with invasive mechanical ventilation. Methods Patients with occupational-related obstructive pulmonary disease who underwent invasive mechanical ventilation in the Department of Respiratory Medicine of our hospital were randomly divided into the conventional group and the treatment group.The patients in the control group was given conventional treatment, and in the observation group was given N-acetylcysteine 600 mg/time on the basis of conventional treatment, nasal feeding, 2 times one day. The levels of PCT, CRP, and IL -6 were observed before treatment and 72 h after treatment; the patient's tracheal intubation time and ICU hospitalization time were calculated. Results There was no significant difference in PCT and hs-CRP IL-6 levels between the two groups before treatment（P＞0.05）. After treatment, the PCT and hs-CRP IL-6 levels were lower than those before treatment. The PCT and hs-CRP IL-6 levels in the observation group were lower than those in the control group（P＜0.05）. The tracheal intubation time and ICU hospitalization time were shorter in the observation group than in the control group（P＞0.05）. After 14 days of treatment, the total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant（P＜0.05）. Conclusion N-acetylcysteine can improve the successful offline rate of patients with COPD and relieve the acute exacerbation after offline.
Key Words：N-acetylcysteine; Mechanical ventilation; Occupational-related obstructive pulmonary disease

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参考文献：

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