中国冶金工业医学杂志

2 型糖尿病患者血清25（OH）D 浓度及骨代谢指标水平的分析

作者：孙春梅李子玲? 路青玉

关键词：T2DM 糖尿病性骨质疏松 25（OH）D PTH P1NP OC β-CTX

分类号：R 587.1

出版年,卷(期):页码：2019,36(3):254-255

摘要：

摘要：目的观察2 型糖尿病（T2DM）患者血清25-羟基维生素D［25（OH）D］、甲状旁腺素（PTH）及全端骨钙素（OC）、I 型胶原氨
基末端前肽（P1NP）、I 型胶原氨基末端前肽（β-CTX）的变化，分析T2DM 患者和非糖尿病者骨代谢指标的差异。方法选取T2DM 患
者166 例作为糖尿病组，并按骨密度测定的T 值分为骨质疏松组、骨量减少组、骨量正常组；另选健康人群62 例作为正常对照组。测
定两组血清25（OH）D、PTH 指标及OC、P1NP 和β-CTX 浓度。结果糖尿病组中骨质疏松及骨量减少例数明显高于正常对照组、
血25（OH）D 和OC 水平低于对照组；糖尿病组与正常对照组的PTH、P1NP 和β-CTX 水平无显著差异，但在糖尿病骨量减少组和骨质疏
松组中P1NP 和β-CTX 水平明显增高。结论T2DM 患者存在维生素D 缺乏现象，其发生骨质疏松以及骨量减少的概率明显增加。可
对T2DM 患者定期进行骨代谢相关检查，以便早期发现并诊断糖尿病性骨质疏松。
关键词：T2DM；糖尿病性骨质疏松；25（OH）D；PTH；P1NP；OC；β-CTX

Abstract：Objective To observe the levels changes of serum 25（OH）D, PTH, OC, P1NP and β-CTX in T2DM, and to analyze the difference of
bone metabolism indexes between type 2 diabetic and non- diabetic patients. Methods 166 cases with T2DM were selected and divided into
osteoporosis group, osteopenia decreased group and normal bone mass group according to T value of bone mineral density, 62 healthy cases as contrast
group. Serum 25（OH）D, PTH, OC, P1NP and β- CTX concentrations were measured. Results The cases number of osteoporosis and osteopenia
decreased in diabetes were more than contrast group, and the blood 25（OH）D, OC concentrations were lower. The level of PTH, P1NP and β-CTX
were no difference between diabetes group and contrast group, but it was significantly higher in the osteopenia decreased group and the osteoporosis
group. Conclusion Vitamin D deficiency is present in patients with T2DM, and the probability of osteoporosis and bone loss are significantly
increased. Diabetic osteoporosis can be detected and diagnosed early by regular monitoring of bone metabolism in patients with T2DM.
Key Words：Type 2 diabetes; Diabetic Osteoporosis; 25（OH）D; PTH; P1NP; OC; β-CTX

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作者简介：

参考文献：

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