Abstract:Objective To understand the level of polio neutralizing antibody among healthy population in Liaoning Province, and provide evidence for scientific assessment of disease risk and vaccine immune effect, and timely adjustment of immunization strategy. Methods Blood serum in different ages among healthy population was collected and the neutralization antibody was tested by micro-neutralization. Results The neutralizing antibodies positive rates for polio I, II and III were 96.79%, 97.15%, 95.15% and the geometric mean antibody titers (GMT) were 1∶104.36, 1∶80.98, 1∶58.38 respectively. The GMT were significantly associated with age, which was decreased with the age increasing. The distribution of antibody positive rates in different regions of the province was uneven, and there were significant differences in antibody positive rates in different regions. Conclusion The positive rates and GMT of polio antibody are maintaining a high-level in Liaoning, and it has formed an effective immune protection barrier.
Key Words:Poliomyelitis; Neutralizing antibody; Geometric mean antibody titer
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