中国冶金工业医学杂志

2型糖尿病一级亲属不同糖调节受损状态胰岛功能的探讨

分类号：R 587

出版年,卷(期):页码：2019,36(5):497-499

摘要：

摘要：目的探讨2型糖尿病一级亲属不同糖调节受损状态胰岛功能。方法选取2型糖尿病患者的一级亲属糖调节异常患者100例，根据OGTT试验结果分为i-IFG组、i-IGT组、IFG & IGT组和仅30或60 min血糖升高组，测定G0、G30、G60、G120和I0、I30、I60、I120。计算稳态模型评估胰岛素抵抗指数（HOMA-IR）、胰岛细胞分泌指数（HOMA-B）、胰岛素峰值与空腹值之比（Imax/I0）及早期相胰岛素分泌指数（ΔI30/ΔG30）。结果（1）HOMA-IR在IFG & IGT组最高，与i-IGT组差异有统计学意义（P＜0.05），其余各组间差异无统计学意义（P＞0.05）。（2）HOMA-B在30或60 min血糖升高组最高，其次为i-IGT组，i-IFG组最低。（3）ΔI30/ΔG30在i-IFG组最高，但各组间比较差异无统计学意义（P＞0.05）。（4）Imax/I0在30或60 min血糖升高组最高，其次为i-IGT组，i-IFG组最低。控制年龄因素后，BMI与HOMA-IR显著正相关（r＝0.303，P＝0.003）。结论 i-IFG组和i-IGT组的差异提示这两组血糖异常人群存在异质性。BMI可以作为评价胰岛素抵抗的简易判定指标。

Abstract：Objective To investigate pancreatic islet function in the first-degree relatives of type 2 diabetic patients with impaired glucose regulation. Methods 100 patients with impaired glucose regulation（IGR） in first-degree relatives of type 2 diabetic patients were selected. According to the results of OGTT test, they were divided into i-IFG group, i-IGT group, IFG & IGT group and only 30 or 60 min of hyperglycemia group. G0, G30, G60, G120, I0, I30, I60, I120 were tested. The steady state model were evaluated to assess insulin resistance index（HOMA-IR）, islet cell secretion index （HOMA-B）, ratio of insulin peak to fasting value（Imax/I0）, and early phase insulin secretion index（ΔI30/ΔG30）. Results （1）HOMA-IR was the highest in the IFG & IGT group, which was significantly different from that in the i-IGT group （P＜0.05）, but there was no significant difference between the other groups（P＞0.05）. （2）HOMA-B was the highest in 30 or 60 minutes of hyperglycemia group, followed by i-IGT group and lowest in i-IFG group. （3）ΔI30/ΔG30 is the highest in i-IFG group, but there was no significant difference among the groups（P＞0.05）. （4）Imax/I0 is the highest in 30 or 60 min of hyperglycemia group was the highest, followed by i-IGT group, i-IFG group was the lowest. After controlling for age, there was a significant positive correlation between BMI and HOMA-IR（r＝0.303，P＝0.003）. Conclusion The difference between i-IFG group and i-IGT group indicates that there is heterogeneity in these two groups . BMI can be used as a convenient index for evaluating insulin resistance.
Key Words：Type 2 diabetes mellitus; First-degree relatives; Impaired glucose regulation; Pancreatic islet function

基金项目：

基金项目：首都医学发展科研基金（项目编号2002-3105）

作者简介：

参考文献：

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