Abstract：Objective To explore the application value of detection of D-dimer and coagulation four items in prenatal examination of pregnant women. Methods 65 pregnant women with pregnancy induced hypertension received in our hospital from May 2017 to April 2018 were selected as group A, 65 normal healthy parturient as group B and 65 healthy women as group C. The levels of serum D-dimer and coagulation four items were compared in the three groups. Results The serum D-dimer level of group A was the highest, followed by group B, while of the group C was the lowest. The difference between the two groups was statistically significant（P＜0.05）. In group A, the level of PT and APTT was the lowest, the level of FIB was the highest, followed by group B, while the level of PT and APTT in group C was the highest, and FIB was the lowest. The differences of the three groups were statistically significant（P＜0.05）. There was no significant difference in TT level between the three groups（P＞0.05）. Conclusion The detection of D-dimer and coagulation four items before pregnancy can effectively prevent postpartum hemorrhage and thrombotic disease and have important value in ensuring the safety of pregnancy and childbirth.