Abstract：Objective To understand the hot issues of international research on hepatitis C, and to provide scientific guidance and reference for fondemantal research, prevention and treatment of hepatitis C in China. Methods Using "hepatitis C" as the theme to retrieve the literatures in the recent 5 years from the PubMed database, the distributions of time, research direction, authors, journals, countries and regions, and the languages were analyzed. Results A total of 14013 literatures were retrieved, and there was a slight decrease in the overall stability, the most of which were the published in 2014 with the number of 3113. Regarding the research topics, the hottest issue was on the treatment of patients with hepatitis C. The author who published the most literatures was Dore G, with 28 articles. The most frequently published journals was Plos One, publishing 592 articles. The authors were mainly from United States, and the literatures mainly originated from English journals. Conclusion In the past five years, the researches on hepatitis C in the world had gradually deepened into various disciplines, and the hotspots had become more widespread, mainly in the field of clinical treatment.