Abstract：Objective To analyze the efficacy of ventilator in the treatment of acute respiratory distress syndrome（ARDS）, and the influence of ventilator on lung function, blood gas and other related indexes. Methods 90 ARDS patients were divided into control group and observation group by random number table method. The patients in the control group were treated with conventional ventilator and in the observation group were treated with comprehensive support of ventilator. The lung function, blood gas, incidence of death and ventilator related complications, ventilator use time, ICU ward treatment time and other indexes of the two groups were compared. Results After treatment, the lung function and blood gas（PaO2、SaO2、PaCO2）in two groups were significantly improved compared to those before treatment, and which in observation group were better in control group. There were significant difference between the two groups（all P＜0.05）. The recovery rate of the observation group was higher than that of the control group. In the control group, the clinical mortality and the incidence of ventilator-associated pneumonia were lower than those in the control group. The ventilator use time and ICU treatment time were shorter than those in the control group, and the differences between the groups were statistically significant（all P＜0.05）. Conclusion The comprehensive supportive treatment of ventilators can improve the efficacy of ARDS, help improve patients?? lung function, shorten treatment time, reduce the incidence of complications, and provide a guarantee for improving the life quality of patients and saving medical costs.