Abstract：Objective To  investigate the treatment and prognosis analysis of acute disseminated encephalomyelitis（ADEM）associated with positive myelin oligodendrocyte glycoprotein（MOG）antibody. Methods 90 patients with MOG antibody positive ADEM who were admitted to our hospital from January 2016 to June 2020 were selected, and divided into control groups and observation group according to different treatment methods, 45 cases in each group. The patient's clinical symptoms were observed, and the immune function indexes and symptom duration of the two groups before and after treatment were compared. Results The clinical symptoms of patients were mainly fever, paralysis, disturbance of consciousness, neck rigidity, etc.The MRI examination of head showed that subcortical white matter patchy lesions（25.56%）, cortex involvement（23.33%）, basal ganglia lesions（17.78%）, brain stem involvement（16.67%）, white matter involvement（11.11%）; After treatment, in the observation group, the levels of the immune function indexes were significantly lower than those in the control group; the duration of fever, disturbance of consciousness and neck ankylosis were shorter than that in the control group. The difference between two groups were all statistically significant（all P＜0.05）. Conclusion The clinical manifestations and head MRI findings of MOG antibody positive ADEM were diverse. Methylprednisolone combined with human immunoglobulin is more effective, which can improve the immunity of patients and promote the recovery of clinical symptoms, and most patients have a good prognosis.