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自拟降糖强心方治疗2型糖尿病合并心力衰竭的临床研究
作者:张园 张世超 
单位:辽宁中医药大学附属医院 辽宁 沈阳 110032 
关键词:关键词:降糖强心方 2型糖尿病 心力衰竭 疗效 
分类号:R 587.1
出版年,卷(期):页码:2021,38(5):497-499
摘要:

 摘要:目的 观察自拟降糖强心方治疗2型糖尿病合并心力衰竭患者的临床疗效。方法 选择2019年1~9月我院诊治的60例2型糖尿病合并心力衰竭患者,按照随机数字表法将其分为对照组与观察组,每组各30例。对照组采用常规降糖联合抗心力衰竭治疗,观察组在对照组基础上口服自拟降糖强心方,两组均连续治疗2个月。比较两组治疗前后FPG、2 hPG、HbA1c、LVEF、NT-ProBNP水平及不良反应。结果 治疗后,两组FPG、2 hPG、HbA1c、NT-ProBNP均低于治疗前,且观察组FPG、2 hPG、NT-ProBNP降低均优于对照组,组间比较差异均有统计学意义(均P<0.05),HbA1c有下降趋势,但组间比较差异无统计学意义(P>0.05);两组LVEF均较治疗前升高,且观察组升高优于对照组,两组比较差异均有统计学意义(均P<0.05);两组不良反应发生率分别为36.67%、16.67%。结论 自拟降糖强心方治疗2型糖尿病合并心力衰竭疗效显著,值得临床研究推广。

 Abstract:Objective To  observe the clinical efficacy of self-made Jiangtang Qiangxin Recipe in the treatment of type 2 diabetes with heart failure. Methods A total of 60 patients with type 2 diabetes and heart failure diagnosed and treated in our hospital from January to September 2019 were divided into a control group and an observation group according to the random number tables,with 30 cases in each group. The patients in the control group were treated with conventional hypoglycemic combined with anti-heart failure treatment,and in the observation group were taking orally with self-made Jiangtang Qiangxin Recipeon the basis of the control group. Both groups were treated for 2 consecutive months. The levels of FPG, 2 hPG, HbA1c, LVEF, NT-ProBNP and adverse reactions before and after treatment were compared between the two groups. Results After treatment, FPG, 2 hPG, HbA1c and NT-ProBNP in the two groups were lower than before treatment and the reduction of FPG, 2 hPG and NT-ProBNP of the observation group were better than that of the control group. The differences between groups were statistically significant(both P<0.05), HbA1c were reduced but the difference between the two groups was not statistically significant(P>0.05); LVEF in the two groups was higher than before treatment, and the increase in the observation group was better than the control group, the difference between the two groups were statistically significant(P<0.05); the incidence of adverse reactions in the two groups were 36.67% and 16.67% respectively. Conclusion The self-made Jiangtang Qiangxin Recipe has significant clinical effect in the treatment of type 2 diabetes with heart failure, and is worthy of clinical research and promotion.

基金项目:
作者简介:
参考文献:

 [1] 中国2型糖尿病防治指南(2017年版)[J]. 中国实用内科杂志,2018,38(4):292-344.

[2] 国家卫生计生委合理用药专家委员会,中国药师协会.心力衰竭合理用药指南(第2版)[J]. 中国医学前沿杂志(电子版),2019,11(7):1-78.
[3] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J]. 中华心血管病杂志,2014,42(2):98-122.
[4] 王令谆.芪参益气滴丸与曲美他嗪联合用于冠心病心力衰竭的疗效观察[J]. 中西医结合心血管病杂志,2016,4(21):51-54.
[5] 秦陆兵,李丰华,唐欣.康复运动对慢性心衰合并2型糖尿病患者外周血脑钠肽、糖化血红蛋白的影响[J]. 中国心血管病研究,2016,16(6):526-530.
[6] 董虹,周莉,刘天春.糖化血红蛋白和BNP检测在糖尿病合并慢性心衰患者中的临床意义分析[J]. 长江大学学报(自科版),2014,11(24):95-97.
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