中国冶金工业医学杂志

PCOS患者中抗苗勒管激素对行IVF-ET助孕的妊娠结局的影响*

作者：彭露张慧龙婷刘云鸽彭丽张先平#

分类号：R 714

出版年,卷(期):页码：2021,38(5):503-505

摘要：

摘要：目的探讨AMH对行IVF-ET助孕的PCOS患者妊娠结局的影响。方法选择2016年7月至2019年10月在我院行IVF-ET治疗的PCOS患者32例为PCOS组，输卵管因素不孕患者48例为对照组，两组均采用IVF-ET助孕治疗，比较两组基础性激素、AMH、AFC、HCG日性激素、Gn使用情况、实验室结局及妊娠结局。结果与对照组比较，PCOS组AMH、bT、bLH、bLH/bFSH、HCG日E2、AFC、获卵数、2PN数、2PN卵裂数、可移植胚胎数均升高，bFSH、HCG日P、HCG日LH、Gn启动剂量与总用量均降低，组间比较差异均有统计学意义（均P＜0.05）；两组bE2、Gn使用时间、优质胚胎数、2PN率、优质胚胎率、生化妊娠率、临床妊娠率比较差异均无统计学意义（均P＞0.05）。结论 AMH、基础性激素、AFC能反映PCOS患者的卵巢储备功能，但AMH不能预测PCOS患者IVF-ET治疗后的妊娠结局。

Abstract：Objective To discuss the influence of AMH on pregnancy outcomes for PCOS patients undergoing IVF-ET. Methods From July 2016 to October 2019 in our hospital, 32 patients with PCOS were selected as the PCOS group and 48 infertility patients with tubal factor were selected as control group, all patients were underwent IVF-ET in two groups. The basal sex hormones, AMH, AFC, HCG daily sex hormone, Gn usage, the laboratory outcomes and pregnancy outcome were compared. Results Compared with the control group, AMH , bT, bLH, bLH/bFSH, E2 of HCG injection day, AFC, total oocytes, the number of 2PN, the number of 2PN cleavage, and the number of transplantable embryos were all increased in the PCOS group, bFSH, the P and LH levels of HCG injection day, Gn start dose, and total Gn dosage in the PCOS group were all reduced, and the differences between groups were statistically significant（all P＜0.05）. The difference of bE2, duration of Gn stimulation, high quality embryos, the rate of 2PN, the rate of high-quality embryos, the rate of pregnancy, the rate of clinical pregnancy in two groups were no statistically significant（all P＞0.05）. Conclusion AMH, basic sex hormones and AFC can reflect the ovarian reserve function of PCOS patients, but AMH could not predict the pregnancy outcome after IVF-ET treatment in PCOS patients.

基金项目：

?基金项目：娄底市科技计划资助项目（娄财企指［2016］384号）；湖南省科技厅基金（NO.2017SK51201）；湖南省卫健委基金（NO.20180420）

作者简介：

参考文献：

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