Abstract：Objective To retrospectively analyzethe clinical effectand the influence on lung function and inflammatory of Hanchuan Zupa Granules combined with interferon atomization inhalation for infantile bronchiolitis. Methods Two hundred and forty children with bronchiolitis were selected and divided into control group and observation group according to treatment methods, with 120 cases in each group, who were treated with interferon atomization inhalation in the control group and in the observation group were combined with Hanchuan Zupa Granules. The clinical efficacy and adverse reactions of two groups were compared. Results The effective rate of observation group was higher than that of control group.The symptoms subsided and hospitalization time were shorter than those in the control group. The difference between the two groups were staticstically significant（all P＜0.05）. After treatment, PaO2 and IL-2 in observation group were higher than that in control group, and PaCO2 and TNF-α were lower than that in control group. The differences between the two groups were statistically significant（all P＜0.05）; there was no statistically significant difference in adverse reactions between the two groups（P＞0.05）. Conclusion Hanchuan Zupa Granules combined with interferon atomization inhalation in the treatment of infantile bronchiolitis has significant efficacy,shortening the course of disease,controlling inflammatory response and high safety.