Abstract：Objective To evaluate the diagnostic value of combined examination of carotid artery color doppler, transcranial doppler and hemorheology in cerebral infarction. Methods From June 2019 to June 2020, 50 patients with cerebral infarction were selected as study group and 50 healthy physical examination during the same period were selected as control group in our hospital. Combined examination of carotid artery color doppler, transcranial doppler and hemorheology was given and the results were compared. Results The carotid plaque existence rate, abnormal blood flow rate and various hemorheological indexes in the study group were higher than those in the control group, and there were significant statistical differences (all P＜0.05). Conclusion The combined examination of three methods has significant diagnostic value for cerebral infarction. Cerebral infarction can be diagnosed and differentiated by detecting hemorheology indicators, observing whether the blood flow rate is abnormal, and whether there are carotid plaques.