Abstract：Objective To  observe the effect of irbesartan combined with amlodipine on the treatment of elderly hypertension. Methods 76 elderly hypertensive patients admitted in our hospital were divided into control group and experimental group according to medicine regiments, with 38 cases in each group. The patients in the control group were treated with irbesartan, and  in experimental group were treated with irbesartan combined with amlodipine, the treatment effect of the two groups were compared. Results The blood pressure of the experimental group was lower than that of the control group after 1 month of treatment. The 24 h urinary protein quantitation, serum creatinine, urea nitrogen and other renal function indexes of the experimental group were superior to those of the control group. The differences between two groups were statistically significance（all P＜0.05）. The incidence of adverse reactions of medication continuous 3 months in the experimental group was higher than that in the control group, the difference between two groups was statistically significance（P＜0.05）. Conclusion The clinic effect of irbesartan combined with amlodipine in elderly hypertensive patients is significantly better than that of irbesartan alone.