中国冶金工业医学杂志

肝动脉灌注化疗栓塞后联合安罗替尼治疗中晚期肝癌临床疗效观察

作者：文艺1 张艳1 龚星云2 李策1

单位：1.攀枝花市第六人民医院肿瘤科四川攀枝花 617023 2.攀枝花大学康养学院

关键词：TACE治疗安罗替尼中晚期肝癌

分类号：R 735.7

出版年,卷(期):页码：2021,38(6):627-628

摘要：

摘要：目的探讨肝动脉灌注化疗栓塞（TACE）后联合安罗替尼治疗中晚期肝癌的疗效及并发症。方法将2019年1月至2020年6月我科收治的28例满足入组条件的中晚期肝癌患者进行TACE联合安罗替尼治疗，评价其临床疗效。结果肿瘤内血流信号消失率为89.3%，甲胎蛋白（AFP）转正常水平占82.1%，肿块缩小率为60.7%，客观缓解率（ORR）和疾病控制率（DCR）分别为53.6%和89.3%，6个月生存率和12个月生存率分别为85.7%和64.3%，2例完全缓解（CR）患者及15例部分缓解（PR）患者中的14例仍在继续接受治疗，未出现非预期性毒性，不良反应可控。结论 TACE后联合安罗替尼治疗中晚期肝癌明显提高了近期疗效，且不增加不良反应。

Abstract：Objective To investigate the efficacy and complications of hepatic artery infusion chemoembolization（TACE）combined with anlotinib for advanced liver cancer. Methods 28 patients with advanced liver cancer in our department who met the inclusion criteria were treated with TACE combined with anlotinib, and the clinical efficacy was evaluated. Results The disappear rate of blood flow signals within tumor was 89.3%, the AFP turn to normal levels was 82.1%, tumor shrink rate was 60.7%, objective response rate（ORR） and disease control rates （DCR）were 53.6% and 89.3%, survival rate of 6 months and 12 months were 85.7% and 64.3% respectively. In 2 cases of complete remission（CR）and 15 cases of partial remission（PR）,14 patients were still receiving treatment, did not appear unexpected toxicity, side effects were controllable. Conclusion TACE combined with anlotinib in the treatment of advanced liver cancer can significantly improve the short-term efficacy, and does not increase the toxic and side effects.

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参考文献：

参考文献

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