Abstract：Objective To  explore the correlation between bilirubin level and N-terminal B-type brain natriuretic peptide precursor（NT-proBNP）and hypersensitive C-reactive protein（hs-CRP）in elderly patients with chronic heart failure（CHF）. Methods All 94 elderly patients with CHF admitted to our hospital from Jan. to Dec. 2019 were divided into cardiac function class II group（n＝32）, cardiac function class III group（n＝31） and cardiac function class IV group（n＝31）according to the cardiac function classification of the New York Heart Association（NYHA）. And 55 patients undergoing clinical health examinations during the same period were selected as the control group. hs-CRP and NT-proBNP in 4 groups were compared. The correlation between hs-CRP, NT-proBNP levels and serum bilirubin levels was calculated by Spearman rank correlation analysis. Results The levels of NT-proBNP, direct bilirubin, indirect bilirubin, total bilirubin and hs-CRP increased gradually with the increase of NYHA cardiac function classification, the difference among groups was statistically significant（F＝1 522.699, 681.319, 251.607, 226.713, 150.188, all P＜0.05）; Serum bilirubin was positively correlated with NT-proBNP and hs-CRP levels（r＝0.558, 0.789, 0.797, 0.429, 0.413, 0.436, all P＜0.05）; One-year follow-up showed that hs-CRP, NT-proBNP and serum bilirubin levels in the cardiovascular event group were significantly higher than those in the non-cardiovascular event group, the difference among groups was statistically significant（t＝11.412, 11.926, 8.434, 4.353, 5.035, all P＜0.05）. Conclusion Dynamic monitoring of the changes of bilirubin in elderly CHF patients is helpful to prevent the occurrence of cardiac events and improve the prognosis of patients.