Abstract：Objective To explore the efficacy and adverse reactions of Yinzhihuang oral liquid combined with bifidobacterium lactobacillus triple live bacteria tablets（Gold bifidobacterium）in the treatment of breast milk jaundice. Methods A total of 184 children with breast milk jaundice diagnosed in our hospital from February 1st. 2017 to May 1st. 2020 were randomly divided into three groups, 58 cases in the combination group, 62 cases in the Yinzhihuang group and 64 cases in the gold bifidobacterium group. The changes of serum total bilirubin level and adverse reactions in the three groups were compared before treatment, 72 hours after treatment, and 72 hours after resumption of breastfeeding. Results The differences were no statistically significant in the level of serum total bilirubin among the three groups（t＝2.1240, P＞0.05）; The value of serum total bilirubin at 72 hours after treatment in the three groups were decreased, but the differences were no statistically significant（t＝4.1772, P＞0.05）; After resumption of breastfeeding for 72 hours, the value of serum total bilirubin were increased in different degree, which in the combination group and the Yinzhihuang group were significantly lower than that in gold bifidobacterium group, the difference between the groups were statistically significant（t＝15.0110, P＜0.05）. Adverse reactions were all occurred in the three groups during treatment. The incidences of red buttocks and diarrhea in the combination group and gold bifidobacterium group were significantly better than that in the Yinzhihuang group, and the differences between the groups were all statistically significant（χ2＝16.9321, 12.1470, all P＜0.05）. Conclusion Yinzhihuang oral liquid combined with gold bifidobacterium has more effective in the treatment of infant breast milk jaundice, with less common adverse reactions and higher safety.