Abstract：Objective To compare the clinical efficacy of transurethral thulium laser enucleation of the prostate（TmLEP）, transurethral plasma kinetic enucleation of prostate（PKEP）and transurethral resection of prostate（TURP）in the treatment of benign prostatic hyperplasia（BPH）. Methods  One hundred and sixty patients with BPH who underwent surgical treatment in our hospital from June 2018 to June 2019 were selected and divided into TmLEP group（n＝55）, PKEP group（n＝53）and TURP group（n＝52）according to the surgical methods. The perioperative indicators of the three groups were compared, prostate function, maximum urinary flow rate, residual urine volume and serum total prostate-specific antigen level before and 3 months after surgery, and the quality of life of the patients at 3 months after surgery was recorded. Results In the TmLEP group, operation time, intraoperative blood loss, mean flushing time, quality of resected tissue, and International Prostate Symptom Score（IPSS）, the maximum urine flow rate（Qmax）, residual urine volume（RUV）, serum total prostate specific antigen（tPSA）, and quality of life scores were better than those in the PKEP group and the TURP group, and the PKEP group was better than the TURP group. The differences between the groups were all statistically significant（F＝11.859, 56.526, 25.463, 11.566, 9.080, 20.378, 14.186, 58.490, 19.000, all P＜0.05）; the incidence of postoperative complications in the TmLEP group was lower than that in the TURP group, and the difference was statistically significant between groups（χ2＝6.528, P＜0.05）; there were all no statistically significant difference in the incidence of postoperative complications between TmLEP group and PKEP group, between the PKEP group and the TURP group（χ2＝1.497, 2.057, all P＞0.05）. Conclusion Compared with PKEP and TURP, TmLEP has more effective in the treatment of BPH and is worthy of application.