设为首页    加入收藏   
首页期刊介绍编委会投稿须知稿约期刊订阅广告合作联系我们留言板

《中国冶金工业医学杂志》 欢迎访问,欢迎查询,欢迎引用!敬告作者投稿成功的标志是收到邮件回执。投稿出现问题邮箱wangtaohong@wangkantong.com,网站技术支持QQ1172987239。

本刊对投稿新要求:1.如果作者是第一次投稿,请务必用自己邮箱注册,并请认真填写作者单位详细通讯地址和第一作者手机,以便能及时准确收到杂志。2.文章必须有中文摘要,近5年参考文献至少3条。详见本刊投稿须知。本刊已同“中国知网”签订独家上网协议。

本刊2024年第2期杂志正在快递寄出,如果有作者没有收到杂志请与本刊编辑部联系,说明第一作者姓名和联系方式。

本刊2024年第2期杂志基本信息已经登载在本刊网站,欢迎读者、作者查询引用。

连续血液净化联合加贝酯治疗重症急性胰腺炎的疗效 和对血清sFlt-1及Visfatin的影响
作者:胡冬根 程丹 
单位:永丰县七都乡卫生院内科 江西 吉安 331506 
关键词:重症急性胰腺炎 加贝酯 sFlt-1 Visfatin 肠黏膜通透性 
分类号:R 576
出版年,卷(期):页码:2023,40(2):131-133
摘要:

 摘要:目的 探讨连续血液净化联合加贝酯对重症急性胰腺炎的疗效和对血清可溶性血管内皮生长因子受体-1(sFlt-1)及内脂素(Visfatin)的影响。方法 选择2017年8月—2019年3月本院就诊并接受治疗的120例重症急性胰腺炎患者,根据治疗方法的不同将其分为对照组与观察组,每组各60例。对照组给予连续血液净化治疗,观察组给予连续血液净化联合加贝酯治疗,对比两组治疗后的临床相关指标、治疗总有效率,治疗前后的血清炎性细胞因子、sFlt-1、Visfatin水平,肠黏膜通透性及不良反应发生率。结果 观察组治疗后的住院时间、腹痛持续时间、排便时间、APACHE评分及腹腔内压均优于对照组,两组比较差异均有统计学意义(t=11.426、3.511、3.329、11.138、5.345,均P<0.05);观察组治疗总有效率高于对照组,两组比较差异有统计学意义(χ2=10.208,P<0.05);观察组治疗后的血清炎性细胞因子、sFlt-1、Visfatin、血清二胺氧化酶、乳果糖/甘露醇的比值均低于治疗前,且观察组降低均优于对照组,两组比较差异均有统计学意义(t=13.379,15.080、9.656、4.307、2.859,3.498、11.188,均P<0.05);两组不良反应发生率比较差异无统计学意义(χ2=0.536,P>0.05)。结论 连续血液净化联合加贝酯对重症急性胰腺炎的治疗效果更好,可有效提高临床疗效,降低血清炎性细胞因子、sFlt-1、Visfatin水平,能减轻炎症反应,保护肠黏膜屏障,未增加不良反应。

 Abstract:Objective To investigate the efficacy of continuous blood purification combined with gabexate on serum soluble vascular endothelial growth factor receptor 1 (sFlt-1) and Visfatin in patients with severe acute pancreatitis. Methods A total of 120 severe acute pancreatitis patients who were treated in our hospital from August 2017 to March 2019 were selected and divided into a control group and an observation group according to the treatment method, with 60 cases in each group. The control group was given continuous blood purification treatment, and the observation group was given continuous blood purification combined with gabexate treatment. The clinical related indexes and total efficacy after treatment, serum inflammatory cytokine,  sFlt-1, Visfatin levels, and intestinal mucosal permeability and incidence of adverse reactions before and after treatment were compared between the two groups. Results After treatment, the length of hospitalization, duration of abdominal pain, defecation time, APACHE score and intra-abdominal pressure in the observation group were all better than those in the control group, and the differences between the two groups were statistically significant (t=11.426, 3.511, 3.329, 11.138, 5.345, all P<0.05); the total effective rate of treatment was higher in the observation group than in the control group, and the differences between the two groups were statistically significant (χ2=10.208, P<0.05); the serum inflammatory cytokines, sFlt-1, Visfatin, serum diamine oxidase, and lactose/mannitol ratios after treatment were all lower than before treatment in the observation group, and the reductions in the observation group were all better than those in the control group, and the differences between the two groups were statistically significant(t=13.379, 15.080, 9.656, 4.307, 2.859, 3.498, 11.188, all P<0.05); the difference in the incidence of adverse reactions between the two groups was not statistically significant (χ2=0.536, P>0.05).  Conclusion Continuous blood purification combined with gabexate has a better therapeutic effect on severe acute pancreatitis, which could effectively improve the clinical efficacy, reduce serum inflammatory cytokines, sFlt-1 and Visfatin levels, reduce inflammation, protect the intestinal mucosal barrier, and not increase adverse reactions.

基金项目:
作者简介:
参考文献:

 参考文献

[1] 王桂良,邱萍,徐林芳,等.生长抑素联合乌司他丁和/或加贝酯治疗重症急性胰腺炎的临床疗效研究[J].中国全科医学,2018,21(34):4241-4245.
[2] 王兴鹏,李兆申,袁耀宗,等.中国急性胰腺炎诊治指南(2013年,上海)[J].胃肠病学,2013,29(7):656-660.
[3] 张宇艳,张海蓉,张景丽,等.连续性血液净化治疗重症急性胰腺炎的研究进展[J].临床肝胆病杂志,2020,36(6):1428-1432.
[4] 姜萌,赵鹏.奥曲肽联合加贝酯治疗重症急性胰腺炎疗效及对患者血清细胞因子水平的影响[J].陕西医学杂志,2020,49(2):212-215.
[5] 王卫伟,王忠玉.大柴胡汤联合连续血液净化治疗急性重症胰腺炎疗效及对血清生化指标,免疫功能与炎性因子的影响[J].现代中西医结合杂志,2020,29(4):426-429.
[6] 何湛,张家敏.乌司他丁联合加贝酯冲击治疗对急性胰腺炎患者炎症水平预后和复发的影响[J].中国药物与临床,2019,19(22):3841-3844.
[7] 段秋琴,王玉月,李伟伟.重度急性胰腺炎患者血清生长素-2和sFlt-1之间的关系及临床意义[J].现代医学,2019,47(8):1017-1022.
服务与反馈:
文章下载】【加入收藏
友情链接   中国知网-中国冶金工业医学杂志 搜狐邮箱 中国知网 中华预防医学会网站 国家新闻出版总署 博文采编官方网站 CNKI翻译助手 网易VIP163邮箱 网易126邮箱 网易163邮箱 雅虎邮箱 新浪邮箱 QQ邮箱 鞍钢总医院网站 丁香园 好医生 疾病查询

《中国冶金工业医学杂志》
编辑部地址:辽宁省鞍山市铁东区健身街3号(鞍钢总医院院内),邮编114002
电话:0412- 6327774 ,0412-6706630,传真:0412-6327774
网址:www.zgyjgyyxzz.com  邮箱:yjyx1984@vip.163.com
京ICP备10041176号