中国冶金工业医学杂志

578例新生儿溶血病3项试验与日龄的关系分析*

作者：尹东杰王荫红#

分类号：R 722.18

出版年,卷(期):页码：2023,40(6):627-629

摘要：

摘要：目的探讨新生儿溶血病（HDN）3项试验与新生儿日龄的关系。方法选取2020年1月—2021年12月我院收治的578例母婴ABO血型不合的新生儿作为研究对象，依据不同日龄将其分为3组，开展溶血病3项试验并进行结果分析。结果年龄≤3 d组的直抗试验阳性率、游离试验阳性率、放散试验阳性率均高于年龄4～7 d组、年龄≥8 d组，组间比较差异均有统计学意义（χ2＝17.685、107.409、73.148，均P＜0.05）；3组新生儿血液样本确诊HDN的阳性率比较，年龄≤3 d组高于年龄4～7 d组、年龄≥8 d组，组间比较差异有统计学意义（χ2＝43.283，P＜0.05）。结论母婴ABO血型不合的新生儿应在3 d内进行溶血病3项检测，新生儿日龄越小，检测阳性率越高。

Abstract：Objective To investigate the relationship between the three hemolysis tests and age in neonates. Methods From January 2020 to December 2021, 578 cases of maternal-infant ABO blood incompatibility admitted to our hospital were selected as the study subjects, and were divided into three groups according to different neonatal age, and the three hemolysis tests were carried out and the results were analyzed. Results The positive rate of direct resistance test, positive rate of free test, and positive rate of discharge test in the age ≤3 d group were higher than those in the age 4 to 7 d group and age ≥8 d group, and the differences were statistically significant in the comparisons between the groups （χ2＝17.685, 107.409, 73.148, all P＜0.05）; the positive rate of blood samples for confirming the diagnosis of HDN in three neonatal group were compared, the age ≤3 d group was higher than age 4 to 7 d group and age ≥8 d group, and the difference between groups was statistically significant （χ2＝43.283, P＜0.05）. Conclusion Newborns with maternal-infant ABO blood incompatibility should be tested the three hemolysis tests within 3 days. The neonate’s age is younger, the rate of positive tests is higher.

基金项目：

?基金项目：淄博市重点研发计划（项目编号：2019zc010146）

作者简介：

参考文献：

参考文献

［1］ Haider Maryam. Rhesus isoimmunization：late-onset hemolytic disease of the newborn without jaundice［J］. Cureus，2020，12（1）：e6559.

［2］陈明，陈小鹤，曾珏，等.母婴ABO血型不合新生儿溶血病的临床与实验室研究［J］.中华全科医学，2018，16（10）：1680-1682.

［3］尚红，王毓三，申子瑜.全国临床检验操作规程［M］.北京：人民卫生出社，2014：139-141.

［4］刘达庄.免疫血液学［M］.上海：上海科学技术出版社，2002：224-225.

［5］ Cao H，Wu R，Han M，et al. Oral administration of Chinese herbal medicine during gestation period for preventing hemolytic disease of the newborn due to ABO incompatibility：a systematic review of randomized controlled trials［J］. PLoS One，2017，12（7）：e0180746.

［6］蔡大凤，荣成智，秦雪，等.新生儿溶血病患儿的实验结果及相关因素分析［J］.检验医学与临床，2020，17（14）：2000-2003.

［7］郭莹莹，霍姿含，王震，等. 1350例新生儿溶血三项试验的血清学检测分析［J］.中国免疫学杂志，2016，32（9）：1357-1359，1363.

［8］薛雷，王俊杰，轩海华.新生儿ABO溶血病试验结果与日龄的关系分析［J］.实验与检验医学，2020，38（5）：976-978.

服务与反馈：

【文章下载】【加入收藏】