Abstract：Objective To explore the diagnostic value of multi-slice spiral CT in mesenteric panniculitis.  Methods The imaging data of 84 patients with mesenteric panniculitis diagnosed and treated in our hospital from January 2012 to December 2021 were retrospectively analyzed, the CT images of patients were observed, and the imaging features of calcification, cystic change, fat ring sign, pseudo-peritoneal sign, enlarged lymph nodes, fibrous tissue nodules and pseudotumor were analyzed.  Results  All patients’ lesions were located in the mesentery, 62 cases of single and 22 cases of multiple, all of them had the pseudo-peritoneal sign, and the soft tissue density area was seen around the changes, with shallow borders, and most of the peritoneal membrane extended to the left lumbar region, presenting anterior and posterior thicker, right side thinner; the CT value of mesenteric lesion tissues was （-60.43±7.33） HU, and that of normal retroperitoneal adipose tissues was （-102.63±7.84） HU, the difference was statistically significant when comparing the data （t＝33.026, P＜0.05）; The imaging features of 77 patients can be seen in the fat ring, surrounded by mass, intraesophageal lymph nodes or low ring density shadow around intestinal vessels around fibrous tissue. 1 case of calcification and 1 case of cystic changes occurred sign; 77 cases showed irregular bands, increased lymph nodes and annular fibrous nodules. Peripheral intestines were displaced in 26 patients; CT had a positive diagnostic rate of 91.7% （77/84）, the negative diagnostic rate of 8.3% （7/84）, the specificity of 9.2% （7/76）, and the sensitivity of 100% （8/8）. Conclusion Multi-slice spiral CT scanning presents a high diagnostic rate in mesenteric panniculitis in terms of pseudotumor, pseudo-fat ring and pseudo-peritoneal sign and is recommended as a noninvasive preferred examination for diagnosis of mesenteric panniculitis.