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美罗培南在重症肺炎患儿临床治疗中的应用研究
作者:董莉 
单位:连云港市妇幼保健院 江苏 连云港 222000 
关键词:美罗培南 头孢哌酮舒巴坦 重症肺炎 临床治疗 研究 
分类号:R 563
出版年,卷(期):页码:2024,41(2):132-133
摘要:

 摘要:目的 探讨重症肺炎患儿应用美罗培南治疗的临床效果。方法 选择2020年1月—2022年1月本院收治并确诊的80例重症肺炎患儿,按照随机数字表法将其分为对照组与观察组,每组各40例。对照组应用头孢哌酮舒巴坦治疗,观察组在对照组基础上联合美罗培南治疗。比较两组临床疗效,血清降钙素原(PCT)、白细胞介素-13(IL-13)、过氧化脂质(LPO)、超氧化物歧化酶(SOD)水平及血气分析指标。结果 观察组治疗有效率高于对照组,两组比较差异有统计学意义(χ2=7.813,P<0.05);观察组治疗后PCT、IL-13、LPO水平均低于对照组,SOD水平高于对照组,两组比较差异均有统计学意义(t=8.729、10.766、11.695、8.780,均P<0.05);观察组治疗后动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)均高于对照组,动脉血二氧化碳分压(PaCO2)低于对照组,两组比较差异均有统计学意义(t=7.783、6.340、9.506,均P<0.05)。结论 对重症肺炎患儿应用头孢哌酮舒巴坦联合美罗培南治疗,能良好地改善患儿病情及相关指标。

 Abstract:Objective To investigate the clinical effect of meropenem in the treatment of children with severe pneumonia. Methods A total of 80 children admitted to our hospital and diagnosed with severe pneumonia from January 2020 to January 2022 were selected and randomly divided into a control group and an observation group, with 40 children in each group. The control group was treated with cefoperazone sulbactam,while the observation group received a combination of cefoperazone sulbactam and meropenem. The clinical efficacy, levels of serum procalcitonin (PCT), interleukin-13 (IL-13), lipid peroxidation (LPO), superoxide dismutase (SOD), and blood gas analysis indicators were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group, with a statistically significant difference (χ2=7.813, P<0.05). After treatment, the levels of PCT, IL-13, and LPO in the observation group were lower, while the level of SOD was higher compared to the control group, with significant differences (t=8.729, 10.766, 11.695, 8.780, all P<0.05). The levels of arterial oxygen pressure (PaO2) and arterial oxygen saturation (SaO2) in the observation group were higher, and the level of arterial carbon dioxide pressure (PaCO2) was lower than that in the control group, with significant differences (t=7.783, 6.340, 9.506, all P<0.05).  Conclusion The combined treatment of cefoperazone sulbactam and meropenem in children with severe pneumonia can effectively improve the clinical condition and related biomarkers of children with severe pneumonia.

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 参考文献

[1] Gilio M,Morella SB,Purgatorio MA,et al. Pos1200 IL-6 higher level after tocilizumab treatment as a predictor of not-survival in COVID19 severe pneumonia:the experience of the covibas-study[J].Annals of the Rheumatic Diseases,2021,80(S1):882.
[2 ] 则学英,安春霞,刘磊.利奈唑胺联合美罗培南治疗重症肺炎疗效观察及对患儿肺泡灌洗液中miR-127-5p、miR-3686表达的影响[J]. 中国药师,2021,24(5):884-888.
[3] 中华人民共和国国家卫生健康委员会.儿童社区获得性肺炎诊疗规范(2019年版)[J].中国实用乡村医生杂志,2019,26(4):6-13.
[4] Li B,Li Z,Cheng W,et al. Application of sputum suction by fiberoptic bronchoscope in patients with severe pneumonia and its effect on inflammatory factors[J]. American Journal of Translational Research,2021,13(7):8409-8414.
[5] 黎代强,陈琳,缪锦松,等.乌司他丁联合美罗培南治疗老年重症肺炎的疗效及对患儿肺氧合功能及血清C反应蛋白、降钙素原水平的影响[J].海南医学,2022,33(1):17-20.
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