Abstract：Objective To investigate the efficacy of Huangqi Guizhi Wuwu Decoction combined with epothilone in the treatment of diabetic peripheral neuropathy.  Methods From January 2021 to January 2023, 86 diabetic patients treated at our hospital were randomly divided into an observation group and a control group, with 43 patients in each group. The control group received epothilone treatment, while the observation group received Huangqi Guizhi Wuwu Decoction combined with epothilone. The clinical efficacy, serum endothelin （ET）levels, motor conduction velocity （MCV）, sensory nerve conduction velocity （SCV）, and inflammatory factor levels were compared between the two groups. Results After treatment, the total effective rate in the observation group was higher than that in the control group, with a statistically significant difference （χ2＝4.441, P＜0.05）. The ET, MCV, SCV, and inflammatory factor levels in the observation group were superior to those in the control group, with statistically significant differences （t＝5.301, 5.982, 6.746, 12.504, 7.051, 7.428, all P＜0.05）. Conclusion The combination of Huangqi Guizhi Wuwu Decoction and epothilone can effectively improve nerve conduction and vascular constriction functions in patients with diabetic peripheral neuropathy, and has a good anti-inflammatory effect.