Abstract：Objective To investigate the value of different dialysis frequencies and modes in the dialysis treatment of uremia patients with chronic renal failure （CRF）.  Methods An Excel spreadsheet was used to compile data on 76 patients with CRF and uremia who were admitted to our hospital from September 2021 to August 2023. They were divided into a control group and an observation group（38 cases in each）based on the dialysis modality. The control group underwent hemodiafiltration, while the observation group underwent hemodiafiltration combined with hemoperfusion. Clinical efficacy and related indicators were compared between the two groups. Results After treatment, the clinical efficacy in the observation group was higher than that in the control group, and the incidence of complications was lower. These differences were statistically significant （χ2＝4.155, 4.547; both P＜0.05）. The levels of various blood parameters, water-electrolyte balance indicators, and inflammatory factors in the observation group were lower than those in the control group. These differences were statistically significant（t＝3.401, 3.223, 2.940, 3.275, 5.681, 7.049, 2.112, 0.559, 13.243, 20.489, 6.489; all P＜0.05）. Conclusion The use of hemodiafiltration combined with hemoperfusion in the treatment of CRF uremia can improve therapeutic outcomes and prognosis while reducing inflammatory factors in the body, making it recommended for clinical implementation.