Abstract：Objective To evaluate the therapeutic efficacy of the photon therapeutic instrument on deep second-degree burn wounds. Methods A total of 120 cases of deep second-degree burn patients admitted to the department of burn surgery, Baogang hospital of Inner Mongolia from April 2018 to April 2020, were selected and randomly divided into a treatment group and a control group, with 60 cases in each group. The treatment group received routine debridement and dressing change every other day, and photon therapy using the Carnation-87 B photon therapy device, while the control group received only conventional debridement and dressing changes. Wound healing rates were compared between the two groups on day 14 and day 21 of treatment, as well as bacterial detection rates from wound exudate on day 21 and overall wound healing time. Results The wound healing rates in the treatment group on day 14 and day 21 were significantly higher than those in the control group, while the bacterial detection rate in wound exudate was significantly lower in the treatment group, with a statistically significant difference（χ2＝4.062, 5.566, 5.175, all P＜0.05）. The treatment group also had a shorter wound healing time compared to the control group, with a statistically significant difference （t＝2.933, P＜0.05）. Conclusion The combination of photon therapy and conventional dressing changes in the treatment of deep second-degree burns is significantly more effective than conventional wound dressing alone. Photon therapy can effectively kill bacteria, reduce infection rates, shorten healing time, and promote wound healing.