 |
电子期刊 >> 正文 |
|
摘要：
|
|
目的:探讨p73、p63和p53在非小细胞肺癌(NSCLC)的表达及与预后的关系.方法:免疫组化法测定93例NSCLC p73、p63和p53的表达并对其与年龄、性别、吸烟、病理类型、组织分化等因素进行统计学分析.结果:p53、p63和p73在正常肺组织表达阳性率分别为25%、25%和12.5%,在NSCLC的表达阳性率分别为65.6%、54.8%和71%,差异有显著性(P＜0.05).p53表达阳性率与淋巴结转移相关(P＜0.05);p63表达阳性率与肺癌的组织类型和淋巴结转移有关(P＜0.05);肺鳞癌组织p63随分化程度降低表达增强(P＜0.05).结论:p53、p63和p73均参与了NSCLC的发展、浸润和转移,可作为了解NSCLC的生物学行为和判断预后的指标.
|
|
|
|
基金项目：
|
|
|
|
作者简介：
|
|
|
|
参考文献：
|
|
Ikawa S.Nakagawara A.Lkawa Y p53 family genes:structural comparison,expression and mutation 1999(12) Tan M.Bian J.Guan K p53CP is p51/p63,the third member of the p53 gene family:partial purification and characterization 2001(2) 王建力.陈莉.王桂兰.曹晓蕾 p63、增殖细胞核抗原和表皮生长因子受体皮肤鳞状细胞癌中的表达 [期刊论文] -中华皮肤科杂志2002(2) Wang BY.Gil J.Kaufman D p63 in pulmonary epithelium,pulmonary squamous neoplasms,and other pulmonary tumors 2002 Massion PP.Taflan PM.Jamshedur Rahman SM Significance of p63 amplification and overexpression in lung cancer development and prognosis 2003 Kahad M.Bonnet H.Yang A Monallelically expressed gene related to p53 at 1p 36,a region frequently deleted in neuroblastoma and other human cancers 1997(4) Mai M.Yokomizo A.Qian C Activation of p73 silent allele in lung cancer 1998(11) Tokuchi Y.Hashimoto T.Kobayashi Y The expression of p73 is increased in lung cancer,independent of p53 gene alteration 1999(10)
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|
|
 |
|
|
 |
|